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KMID : 0613820070170101381
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Journal of Life Science
2007 Volume.17 No. 10 p.1381 ~ p.1386
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Changes in Physiological Activities of Scutellariae baicalensis by Heating
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Choi Myeong-Rak
Lim Hyun-Soo
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Abstract
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To elucidate the changes in physiological activities of Scutellariae baicalensis by heating, composition analysis with HPLC and evaluation of physiological activities of extracts were conducted. HPLC analysis of CW(water extract at room temperature) and CHW(heat treated CW) indicated that two distinctive peaks in the HPLC chromatogram were disappeared after boiling and additional peak was newly observed. This observation suggested that certain chemical changed in the extract occurred by heat treatment. In the estimation of physiological activities, CW showed higher ACE inhibiting activity than CHW. In the case of cytotoxic activity against cancer cells, CW exhibited higher activity than CHW against CCL-185. On the other hand, CHW showed higher activity than CW against HeLa, SNU-601 and HepG2. In addition, CHW showed the inhibitory effect on melanogenesis (80% inhibition) while CW did not show any activity.
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KEYWORD
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Scutellariae baicalensis, peak analysis, antioxidative activity, cytotoxic activity, melanogenesis
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